*: indicates corresponding authorship.    #: indicates equal contribution. 

2020

Gegg C, Yang F*. “Spatially patterned microribbon-based hydrogels induce zonally-organized cartilage regeneration by stem cells in 3D”. Acta Biomaterialia 101, 196-205. | Article

Gegg C, Yang F*. “The Effects of ROCK Inhibition on Mesenchymal Stem Cell Chondrogenesis Are Culture Model Dependent”, Tissue Engineering Part A 26 (3-4), 130-139. | Article

Conrad B, Hayashi C, Yang F* . “Gelatin-based microribbon hydrogels support robust MSC osteogenesis across a broad range of stiffness”, ACS Biomaterials Science & Engineering, 2020 Apr, 6(6): 3454-3463; | Article

Barati D, Watkins K, Wang Z, Yang F* . “Injectable and Crosslinkable PLGA‐Based Microribbons as 3D Macroporous Stem Cell Niche”. Small, 2020 Jun; 16(22):e1905820. doi: 10.1002/smll.201905820. Epub 2020 Apr 27. PMID: 32338432 | Article

Ueno M, Utsunomiya T, Kohno Y, Maruyama M, Zhang N, Lin TD, Yao Z, Zwingenberger S, Yang F, Goodman SB. “Genetically modified IL-4 over- expressing MSCs enhance bone healing”, Cytotherapy, 22(5):S178, 2020 May, doi: 10.1016/j.jcyt.2020.03.372.| Article

 

Ueno M, Lo CW, Barati D, Conrad B, Lin TH, Kohno Y, Utsunomiya T, Zhang N, Maruyama M, Rhee C, Romero-Lopez M, Khan T, Tong X, Yao Z, Zwingenberger S, Yang F*, Goodman SB. “IL-4 overexpressing mesenchymal stem cells within gelatin-based microribbon hydrogels enhance Bone Healing in a Murine Long Bone Critical-size Defect Model”, Journal of Biomedical Materials Research: Part A. 2020 Nov 1; 108(11):2240-2250. doi: 10.1002/jbm.a.36982. PMID: 32363683 | Article

 

Barati D#, Gegg C#, Yang F*. "Nanoparticle-mediated TGF-β Release from Microribbon-based Hydrogels Accelerates Stem Cell-based Cartilage Formation in vivo", Annals of Biomedical Engineering 2020 Jul; 48 (7): 1971-1981. doi: 10.1007/s10439-020-02522-z. Epub 2020 May 6. PMID: 32377980. #: Equal contribution. | Article

 

Tang Y, Tong X, Conrad B, Yang F*. "Injectable and in situ Crosslinkable Gelatin Microribbon Hydrogels for Stem Cell Delivery and Bone Regeneration in vivo".Theranostics, 2020 May; 10(13): 6035–6047. doi: 10.7150/thno.41096, PMID: 32483436. | Article

 

Gegg C, Tong X, , Yang F*. “Mixed composition microribbon hydrogels induce rapid and synergistic cartilage regeneration by MSCs in 3D via paracrine signal exchange”. ACS Biomaterials Science & Engineering, 2020 May, doi: 10.1021/acsbiomaterials.0c00131 | Article

 

Wang C, Sinha S, Jiang X, Murphy L, Fitch S, Wilson C, Grant G, Yang F*. “Matrix stiffness modulates patient-derived glioblastoma cell fates in 3D hydrogels”, Tissue Engineering Part A,2020 July, DOI: 10.1089/ten.TEA.2020.0110. PMID: 32731804

| Article

Murphy M, Koepke LS, Lopez MT, Tong X, Ambrosi TH, Gulati GS, Marecic O, Wang Y, Ransom RC, Hoover MY, Steininger H, Zhao LM, Walkiewicz MP, Quarto N, Levi B, Wan D, Weissman IL, Goodman SB, Yang F, Longer MT, Chan CK. "Articular cartilage regeneration by activated skeletal stem cells". Nature Medicine, 2020 Aug 17, doi: 10.1038/s41591-020-1013-2. PMID: 32807933.

| Article

 

Zhu D, Trinh P, Li J, Grant GA, Yang F*. “Gradient hydrogels for screening stiffness effects on patient-derived glioblastoma xenograft cell fates in 3D”, J Biomed Mater Res A, 2020 Aug 30. Doi: 10.1002/jbm.a.37093. PMID: 32862485. Online ahead of print. | Article

 

Wang C, Sinha S, Jiang X, Fitch S, Wilson C, Caretti V, Ponnuswami A, Monje M, Grant G, Yang F*. “A comparable study of brain tumor cells from different age and anatomical locations using 3D biomimetic hydrogels”, Acta Biomater, 2020 Sep 7;S1742-7061(20)30521-3. doi: 10.1016/j.actbio.2020.09.007. PMID: 32911104. | Article

2019

Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A,McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M,Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. “A Premature TerminationCodon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via ChronicActivation of Nonsense-Mediated Decay.” Circulation. 2019 Feb 5;139(6):799-811.doi: 10.1161/CIRCULATIONAHA.118.034624. PMID:30586709. | Article

​Stanton AE, Tong X, Lee S, Yang F*. “Biochemical Ligand Density Regulates Yes-Associated Protein Translocation in Stem Cells through Cytoskeletal Tension andIntegrins”. ACS Appl. Mater. Interfaces 2019, 11, 9, 8849-8857. 2019 Feb 21, doi: 10.1021/acsami.8b21270 | Article

​Rogan H, Ilagan F, Yang F*. “Comparing Single Cell Versus Pellet Encapsulationof Mesenchymal Stem Cells in Three-Dimensional Hydrogels for Cartilageregeneration."Tissue Eng Part A. 2019 May 2. doi: 10.1089/ten.TEA.2018.0289.[Epub ahead of print] PMID: 30672386 | Article

​Lee S, Stanton AE, Tong X, Yang F*. “Hydrogels with enhanced protein conjugationefficiency reveal stiffness-induced YAP localization in stem cells depends onbiochemical cues.” Biomaterials. 2019 May;202:26-34.  doi: 10.1016/j.biomaterials.2019.02.021. Epub 2019 Feb 23. PMID: 30826537 | Article

​Wang C, Li J, Sinha S, Peterson A, Grant GA, Yang F*. “Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor andendothelial cells in 3D hydrogels.” Biomaterials. 2019 May; 202:35-44. doi:10.1016/j.biomaterials.2019.02.024. Epub 2019 Feb 27. PMID: 30836243 | Article

Lin T, Kohno Y, Huang JF, Romero-Lopez M, Maruyama M, Ueno M, Pajarinen J,Nathan K, Yao Z, Yang F, Wu JY, Goodman SB. “Preconditioned or IL4-SecretingMesenchymal Stem Cells Enhanced Osteogenesis at Different Stages.” TissueEng Part A. 2019 Aug;25(15-16):1096-1103. doi: 10.1089/ten.TEA.2018.0292. Epub 2019 Mar 27. PMID: 30652628 | Article 

Stanton AE, Tong X, Yang F*. “Extracellular matrix type modulates mechanotransduction of stem cells” Acta Biomater. 2019 Sep 15;96:310-320. doi: 10.1016/j.actbio.2019.06.048. Epub 2019 Jun 28. PMID: 31255664. | Article

Rogan H, Yang F*. “Optimizing 3D Co-culture Models to Enhance Synergy BetweenAdipose-Derived Stem Cells and Chondrocytes for Cartilage Tissue Regeneration”.Regenerative Engineering and Translational Medicine, 2019 Sep, 5:3, pp270-279. | Article

​Stanton AE, Tong X, Yang F*. “Varying solvent type modulates collagen coatingand stem cell mechanotransduction on hydrogel substrates”. APLBioengineering. 2019 Sep 30;3(3):036108. doi: 10.1063/1.5111762. eCollection2019 Sep. PMID: 31592041 | Article

​Conrad B, Hayashi C, Yang F*. “Gelatin-based microribbon hydrogels guidedmesenchymal stem cells to undergo endochondral ossification in vivo with bone-mimicking mechanical strength”. Regenerative Engineering and TranslationalMedicine, Published Dec 10 2019, https://doi.org/10.1007/s40883-019-00138-x | Article

​Rogan H, Ilagan F, Tong X, Chu CR, Yang F*. “Microribbon-hydrogel compositescaffold accelerates cartilage regeneration in vivo with enhanced mechanicalproperties using mixed stem cells and chondrocytes”. Biomaterials. 2020Jan;228:119579. doi: 10.1016/j.biomaterials.2019.119579. Epub 2019 Oct31.PMID: 31698227 | Article

Gegg C, Yang F*. “Spatially patterned microribbon-based hydrogels induce zonally-organized cartilage regeneration by stem cells in 3D”. Acta Biomater. 2020 Jan 1;101:196-205. doi: 10.1016/j.actbio.2019.10.025. Epub 2019 Oct 19. PMID: 31634627. | Article

​Gegg C, Yang F*. "The Effects of ROCK Inhibition on Mesenchymal Stem CellChondrogenesis Are Culture Model Dependent." Tissue Eng Part A. 2020Feb;26(3-4):130-139. doi: 10.1089/ten.TEA.2019.0068. Epub 2019 Sep 20. PMID:31411113. | Article

​González Díaz EC, Sinha S, Avedian RS, Yang F*. "Tissue-engineered 3D models forelucidating primary and metastatic bone cancer progression." Acta Biomater. 2019Nov;99:18-32. doi: 10.1016/j.actbio.2019.08.020. Epub 2019 Aug 13. Review. PMID:31419564. | Article

2018

Zhu D, Tong X, Trinh P, Yang F*."Mimicking cartilage tissue zonal organization by engineering tissue-scale gradient hydrogels as 3D cell niche". Tissue Eng Part A. 2018 Jan;24(1-2):1-10. doi: 10.1089/ten.TEA.2016.0453. Epub 2017 Aug 22. | Article

 

Wang T, Yang F*."A comparative study of chondroitin sulfate and heparin sulfate for directing chondrogenesis of mesenchymal stem cells in 3D". Stem Cell Res Ther, 2017 Dec 19;8(1):284. doi: 10.1186/s13287-017-0728-6. | Article

 

Jiang X, Wang C, Fitch S, Yang F*."Targeting tumor hypoxia using nanoparticle-engineered CXCR4-overexpressing adipose-derived stem cells" Theranostics. 2018 Feb 2;8(5):1350-1360. doi: 10.7150/thno.22736. eCollection 2018. | Article

 

Conrad B, Han L, Yang F*."Gelatin-based microribbon hydrogels accelerate cartilage formation by mesenchymal stem cells in 3D", Tissue Engineering Part A , 2018 Jun 21. doi: 10.1089/ten.TEA.2018.0011. | Article

 

Zhu D,Trinh P, Liu E, Yang F*."Biochemical and Mechanical Gradients Synergize to Enhance Cartilage Zonal Organization in 3D". ACS Biomaterials Science & Engineering. August 2018, DOI: 10.1021/acsbiomaterials.8b00775. | Article

 

Tong, X., Yang F*. "Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration", Advanced Healthcare Materials, 2018 Apr;7(7):e1701065. doi: 10.1002/adhm.201701065. Epub 2017 Dec 27. | Article

 

2017

Tevlin R, Seo E, Marecic O, McArdle A, Tong X, Zimdahl B, Malkovskiy A, Sinha R, Gulati G, Li X, Wearda T, Morganti R, Lopez M, Ransom RC, Duldulao CR, Rodrigues M., Nguyen A, Januszyk M, Maan Z, Paik K, Yapa KS, Rajadas J, Wan DC, Gurtner GC, Snyder M, Beachy PA, Yang F, Goodman SB, Weissman IL, Chan C, Longaker MT. "Pharmacological rescue of diabetic skeletal stem cell niches". Science Translational Medicine 2017 Jan 11;9(372). pii: eaag2809. doi: 10.1126/scitranslmed.aag2809. PMID:28077677. | Article

 

Nabeshima A, Pajarinen J, Lin TH, Jiang X, Gibon E, Cordova LA, Loi F, Lu L, Jamsen E, Egashira K, Yang F, Yao Z, Goodman SB. "Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model", Radiology, 2017 Feb;117:1-9. doi: 10.1016/j.biomaterials.2016.11.039. Epub 2016 Nov 24. | Article

 

Zhu D#, Wang H#, Trinh P, Heilshorn S*, Yang F*."Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration". (*:co-first authors, # : co-corresponding author). Biomaterials, 2017 May;127:132-140. doi: 10.1016/j.biomaterials.2017.02.010. Epub 2017 Mar 3. PMID: 28268018. (#: co-first authors, *: Co-corresponding authors). | Article

 

Wang H, Zhu D, Paul A, Cai L, Enejder A, Yang F, Heilshorn S. "Covalently adaptable elastin-like protein – hyaluronic acid (ELP – HA) hybrid hydrogels with secondary thermoresponsive crosslinking for injectable stem cell delivery". Adv. Funct. Mater. 2017 May 19; 27, 1605609. | Article

 

Serpooshan V, Chen P, Wu H, Lee S, Sharma A, Hu D, Venkatraman S, Ganesan AV, Yang F, Wu JC, Demirci U, Wu SM. "Bioacoustic-enabled assembly of human iPSC-derived cardiomyocytes into 3D cardiac tissue". Biomaterials, 2017 Jul;131:47-57. doi: 10.1016/j.biomaterials.2017.03.037. Epub 2017 Mar 28. PMID: 28376365. | Article

 

Lee S#, Serpooshan V#, Tong X, Venkatraman S, Lee M, Wu SM*, Yang F*."Contractile force generation by 3D hiPSC-derived cardiac tissue is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness". (#:co-first authors, * : co-corresponding author). Biomaterials, 2017 Jul;131:111-120. doi: 10.1016/j.biomaterials.2017.03.039. Epub 2017 Mar 30. PMID: 28384492. | Article

 

Daldrup-Link HE, Chan C, Lenkov O, Taghavigarmestani S, Nazekati T, Nejadnik H, Chapelin F, Khurana A, Tong X, Yang F, Pisani L, Longaker M, Gambhir SS. "Detection of stem cell transplant rejection with ferumoxytol-MR Imaging: Correlation of MRI findings with intravital microscopy", Radiology, 2017 Aug;284(2):495-507. doi: 10.1148/radiol.2017161139. Epub 2017 Jan 27. PMID: 28128708. | Article

 

2016

Lee S, Tong X, Yang F*. "Effect of poly(ethylene glycol) hydrogel crosslinking mechanism on protein release." Biomaterials Science. 2016,4, 405-411, DOI: 10.1039/C5BM00256G, Epub 2015 Nov 5. | Article

 

Lee S, Tong X, Han LH, Behn A, Yang F*. "Aligned microribbon-like hydrogels for guiding three-dimensional smooth muscle regeneration" Journal of Biomedical Materials Research: Part A. 2016 May;104(5):1064-71. doi: 10.1002/jbm.a.35662. Epub 2016 Feb 14. | Article

 

Tong X, Jiang J, Zhu D, Yang F*. "Hydrogels with dual gradients of mechanical and biochemical cues for deciphering cell-niche interactions". ACS Biomaterials Science & Engineering. 2016, 2 (5), pp 845–852, DOI: 10.1021/acsbiomaterials.6b00074, Epub March 16, 2016. | Article

 

Deveza L, Choi J, Lee J, Huang N, Cooke J, Yang F*. "Polymer-DNA nanoparticle induced CXCR4 overexpression improves stem cell engraftment and tissue regeneration in a mouse hindlimb ischemia model." Theranostics, 2016 May 23;6(8):1176-89. doi: 10.7150/thno.12866. eCollection 2016. | Article

 

Han LH, Chung MT, Deveza L, Jiang X, Conrad B, Wang A, Butte MJ, Longaker MT, Wan D, Yang F*. "Microribbon-based hydrogels accelerate stem cell-based bone regeneration in a mouse critical-size cranial defect model". J Biomed Mater Res A. 2016 Jun;104(6):1321-31. doi: 10.1002/jbm.a.35715. Epub 2016 Apr 9. | Article

 

Keeney M*, Chuang MT*,Paik KJ, McArdle A, Morrison SD, Ransom C, Barbhaiya N, Zielins ER, Atashroo D, Jacobson G, Zare RN, Longaker MT, Wan DC, Yang F*, "Scaffold-mediated BMP-2 minicircle DNA delivery accelerated bone repair in a mouse critical-size calvarial defect model" (*: co-first authors, #: co-corresponding authors). J Biomed Mater Res A. 2016 Aug;104(8):2099-107. doi: 10.1002/jbm.a.35735. Epub 2016 Jun 3. (Epub ahead of print). (*: co-first authors, #: co-corresponding authors). | Article

 

Sato T, Pajarinen J, Behn A, Jang X, Lin T, Loi F, Yao Z, Egashira K, Yang F, Goodman SB. "The Effect of Local IL-4 Delivery or CCL2 Blockade on Implant Fixation and Bone Structural Properties in a Mouse Model of Wear Particle Induced Osteolysis". J Biomed Mater Res A. 2016 Sep;104(9):2255-62. doi: 10.1002/jbm.a.35759. Epub 2016 May 10. | Article

 

Tong X, Yang F*. "Sliding hydrogels with mobile molecular ligands and crosslinks as 3D stem cell niche", Advanced Materials, 2016 Sep;28(33):7257-63. doi: 10.1002/adma.201601484. Epub 2016 Jun 15. | Article

 

Wang C, Tong X, Jiang X, Yang F*. "The effect of matrix metalloproteinase-mediated matrix degradation on glioblastoma cell behavior in 3D PEG-based hydrogels". Journal of Biomedical Materials Research Part A, 2017 Mar;105(3):770-778. doi: 10.1002/jbm.a.35947. Epub 2016 Nov 18. | Article

 

Jiang X, Fitch S, Wang C, Wilson C, Li JF, Song B, Grant G, Yang F*. "Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery", Proc Natl Acad Sci USA, 2016 Nov 29;113(48):13857-13862. Epub 2016 Nov 14. | Article

 

Wang T, Lai JH, Han LH, Tong X, Yang F*. "Modulating stem cell-chondrocyte interactions for cartilage repair using combinatorial extracellular matrix-containing hydrogels". J. Mater. Chem. B, 2016 Nov; 4, 7641-7650. DOI: 10.1039/C6TB01583B. | Article

Wang T, Lai JH, Yang F*. "Effects of hydrogel stiffness and extracellular compositions on modulating cartilage regeneration by mixed populations of stem cells and chondrocytes in vivo", Tissue Engineering Part A, 2016 Dec;22(23-24):1348-1356 | Article

 

2015

Smeriglio P#, Lai JH#, Dhulipala L, Behn AW, Goodman SB, Smith RL, Maloney WJ , Yang F* and Bhutani N*. "Comparative Potential of Juvenile and Adult Human Articular Chondrocytes for Cartilage Tissue Formation in 3D Biomimetic Hydrogels" (#: equal contribution, *: co-corresponding authors). Tissue Eng Part A. 2015 Jan;21(1-2):147-55. doi: 10.1089/ten.TEA. 2014.0070. Epub 2014 Oct 1 | Article

 

Smeriglio P, Dhulipala L, Lai JH, Goodman SB, Dragoo JL, Smith RL, Maloney WJ, Yang F*#, and Bhutani N. "Collagen VI enhances Cartilage tissue generation by stimulating Chondrocyte proliferation" Tissue Eng Part A. 2015 Feb;21(3-4):840-9. doi:10.1089/ten.TEA.2014. 0375. Epub 2014 Nov 11. | Article

 

Lai JH, Kajiyama G, Smith RL, Maloney W, Goodman SB, Yang F*. "Interactions between Osteoarthritic Chondrocytes and Adipose-Derived Stem Cells is Dependent upon Cell Distribution in in three-dimension and transforming growth factor-β3 induction" Tissue Eng Part A. 2015 Mar;21(5-6):992-1002. doi: 10.1089/ten.TEA.2014.0244. Epub 2015 Feb 6. | Article

 

Nejadnik H, Diecke S, Lenkov OD, Chapelin F, Donig J, Tong X, Derugin N, Chan RC, Gaur A, Yang F, Wu JC, Daldrup-Link HE. "Improved approach for chondrogenic differentiation of human induced pluripotent stem cells." Stem Cell Rev. 2015 Apr;11(2):242-53. doi: 10.1007/s12015-014-9581-5. | Article

 

 Deveza L, Ashoken J, Casteneda G, Keeney M, Tong X, Han L, Yang F*. "Microfluidic Synthesis of Biodegradable Polyethylene-Glycol Microspheres for Controlled Delivery of Proteins and DNA Nanoparticles" ACS Biomater. Sci. Eng., 2015, 1 (3), pp 157–165. DOI: 10.1021/ab500051v. Epub Feb 10, 2015. | Article

 

Lee J, Taylor SE, Smeriglio P, Lai J, Maloney WJ, Yang F, Bhutani N. "Early induction of a prechondrogenic population allows efficient generation of stable chondrocytes from human induced pluripotent stem cells". FASEB J. 2015 Apr 24. pii: fj.14-269720. [Epub ahead of print] | Article

 

Jiang X, Taishi S, Yao ZY, Keeney M, Pajarinen J, Lin TH, Loi F, Egashira K, Goodman S, Yang F*. "Local delivery of mutant CCL2 protein reduced orthopaedic implant wear particle-induced osteolysis and inflammation in vivo." Journal of Orthopaedic Research 2016 Jan;34(1):58-64. doi: 10.1002/jor.22977. Epub 2015 Jul 29. | Article

 

Tong X, Lee S, Bararpour L, Yang F*. "Long-term controlled protein release from poly(ethylene glycol) hydrogels by modulating mesh size and degradation." Macromolecular Biosciences. 2015 Dec;15(12):1679-86. doi: 10.1002/mabi.201500245. Epub 2015 Aug 11. | Article

 

Smeriglio P, Lai JH, Yang F, Bhutani N. "3D hydrogel scaffolds for articular chondrocyte culture and cartilage generation." J Vis Exp. 2015 Oct 7;(104). doi: 10.3791/53085. | Article

 

Keeney M, Yammane M, Lee M, Yang F*. "Nanocoating for biomolecule delivery using layer-by-layer self-assembly." Journal of Materials Chemistry B, 2015 Sep, 3, 8757-8770. | Article

 

2014

Han LH, Tong X, Yang F*. "Photocrosslinkable PEG-based Microribbons for Forming 3D Macroporous Scaffolds with Decoupled Niche Properties". Advanced Materials, 2014 Mar 19, 26 (11):1757-1762. Epub 2013 Dec 17, DOI: 10.1002/adma.201304805. | Article

 

Hammer J#, Han LH#, Tong X, Yang F*. "A Cell-friendly Process to Fabricate Hydrogels with Microchannel-like Porosity for Tissue Engineering." Tissue Engineering, Part C Methods. 2014 Feb;20(2):169-76. doi: 10.1089/ten.TEC.2013.0176. Epub 2013 Jul 17. (#: Equal contribution) | Article

 

Tong X, Yang F*. "Engineering Interpenetrating Network Hydrogel as Biomimetic Cell Niche with Independently Tunable Biochemical and Mechanical Properties." Biomaterials 2014 Feb;35(6):1807-15. doi: 10.1016/j.biomaterials.2013.11.064. Epub 2013 Dec 9. | Article

 

Wang C, Tong X, Yang F*. "Bioengineered 3D Brain Tumor Model to Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior using PEG-based Hydrogels" Molecular Pharmaceutics, 2014 Jul 7;11(7):2115-25. doi: 10.1021/mp5000828. Epub 2014 Apr 29. | Article

 

Wang TY, Lai JH, Han LH, Tong X, Yang F*. "Chondrogenic differentiation of adipose-derived stromal cells in Combinatorial Hydrogels Containing Cartilage Matrix Proteins with Decoupled Mechanical Stiffness". Tissue Engineering Part A, 2014 Aug;20(15-16):2131-2139. Epub 2014 Apr 7. doi:10.1089/ten.tea.2013.0531. | Article

 

Lin TH, Yao Z, Sato T, Keeney M, Li C, Pajarinen J, Yang F, Egashira K, Goodman SB, "Suppression of wear particle induced pro-inflammatory cytokine and chemokine production in macrophages via NF-kappa B decoy oligodeoxynucleotide: A preliminary report". Acta Biomaterialia, 2014 Aug;10(8):3747-55. doi: 10.1016/j.actbio.2014.04.034. Epub 2014 May 9. | Article

 

Yao Z, Keeney M, Lin T, Barcay K, Water H, Pajarinen J, Egashira K, Yang F*, Goodman S. "Mutant MCP-1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopaedic implant wear particles". J Biomed Mater Res A 2014 Sep;102(9):3291-7. doi: 10.1002/jbm.a.34981. Epub 2013 Nov 20. | Article

 

Madl C, Keeney M, Li X, Han LH, Yang F*. "Co-release of cells and polymeric nanoparticles from sacrificial microfibers enhances non-viral gene delivery inside 3D hydrogels." Tissue Engineering Part C Methods, 2014 Oct;20(10):798-805. doi: 10.1089/ten.TEC.2013.0669. Epub 2014 Apr 4. | Article

 

Lee S, Tong X, Yang F*. "The Effects of Varying Poly(ethylene glycol) Hydrogel Crosslinking Density and Crosslinking Mechanism on Protein Accumulation in Three-dimensional Hydrogels" Acta Biomaterialia, 2014 Oct;10(10):4167-74. doi: 10.1016/j.actbio.2014.05.023. Epub 2014 Jun 2. | Article

 

Goodman SB, Gibon E, Pajarinen J, Lin TH, Keeney M, Ren PG, Nich C, Rao A, Yao Z, Egashira K, Yang F, Konttinen YT. "Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement". Journal of the Royal Society Interface, 2014 Jan 29;11(93):20130962. doi: 10.1098/rsif.2013.0962. Print 2014 Apr 6.

| Article

2013

Deveza L, Choi J, Imanbayev G, Yang F*. "Paracrine Release from Non-viral Engineered Adipose Derived Stromal Cells Promotes Endoethelial Cell Survival and Migration in vitro", Stem Cells and Development, 2013 Feb 1;22(3):483-91. Epub 2012 Aug 13. | Article

 

Nauta A, Seidel C, Deveza L, Montoro D, Grova M, Ko SH, Hyun J, Gurtner G, Longaker MT, Yang F*. "Adipose Derived Stromal Cells Overexpressing Vascular Endothelial Growth Factor Accelerate Wound Closure in a Mouse Excisional Wound Healing Model", Molecular Therapy, 2013 Feb;21(2):445-55. Epub 2012 Nov 20. | Article

 

Han LH, Yu S, Wang TY, Behn AW, Yang F*. "Microribbon-like Elastomers for Fabricating Macroporous and Highly Flexible Scaffolds that Support Cell Proliferation in 3D", Advanced Functional Materials, 2013 Jan; 23:346–358. Epub 2012 Sep 4. (Highlighted as journal cover image) | Article

 

Nii M, Lai J, Keeney M, Han LH, Behn A, Imanbayev G, Yang F*. "The effects of Interactive Mechanical and Biochemical Niche Signaling on Osteogenic Differentiation of Adipose-derived Stem Cells Using Combinatorial Hydrogels", Acta Biomaterialia, 2013 Mar;9(3):5475-83. Epub 2012 Nov 12.  | Article

 

Chung MT, Liu CJ, Hyun JS, Lo DD, Montoro DT, Hasegawa M, Li S, Sorkin M, Rennert R, Keeney M, Yang F, Quarto N, Longaker M, Wan DC. "CD90 (Thy-1) Positive Selection Enhances Osteogenic Capacity of Human Adipose-Derived Stromal Cells." Tissue Engineering Part A. 2013 Apr;19(7-8):989-97. Epub 2013 Jan 28. | Article

 

Keeney M, Mathur M, Cheng E, Yang F*. "The Effects of Polymer End-group Chemistry and Order of Deposition on Controlled Protein Delivery from Layer-by-layer Assembly", Biomacromolecules, 2013, 14 (3): 794–800. Epub 2013 Jan 29. | Article

 

Ramasubramanian A#, Jeeawoody S#, Yang F*. "Gene Delivery of Osteoinductive Signals to a Human Fetal Osteoblast Cell Line Induces Apoptosis in a Dose-Dependent Manner". Drug Delivery and Translational Research. 2013 July 13 Epub ahead of print (#: equal contribution). | Article

 

Keeney M#, Ong SG#, Padilla A, Yao Z, Goodman S, Wu J, Yang F*. "Development of Poly (β-amino esters)-Based Biodegradable Nanoparticles for Non-viral Delivery of Minicircle DNA." ACS Nano., 2013, 7 (8), pp 7241-7250. Epub July 9, 2013 (#: equal contribution). | Article

 

Keeney M, Onyiah S, Zhang Z, Tong X, Han LH, Yang F*. "Modulating Polymer Chemistry to Enhance Non-viral Gene Delivery inside Hydrogels with Tunable Matrix Stiffness". Biomaterials. 2013 Dec;34(37):9657-65. doi: 10.1016/j.biomaterials.2013.08.050. Epub 2013 Sep 5. | Article

 

Keeney M#, Deveza L#, Yang F*. "Programming Stem Cells for Therapeutic Angiogenesis using Biodegradable Polymeric Nanoparticles". The Journal of Visualized Experiment. 2013 Sep 27;(79):e50736. doi: 10.3791/50736. (#: equal contribution.) | Article

 

Keeney M, Waters H, Barcay K, Jiang XY, Yao Z, Pajarinen J, Egashira K, Goodman S, Yang F*. "Mutant MCP-1 Protein Delivery from Layer-by-Layer Coatings on Orthopaedic Implants to Modulate Inflammatory Response". Biomaterials. 2013 Dec;34(38):10287-95. doi: 10.1016/j.biomaterials.2013.09.028. Epub Sep 26. 2013. | Article

 

Lai JH, Kajiyama G, Smith RL, Maloney W,Yang F*.“Stem cells catalyze cartilage formation by neonatal chondrocytes in 3D biomimetic hydrogels”. Scientific Reports 3, Article number: 3553 (2013) doi:10.1038/srep03553 | Article

 

Goodman S, Yao Z, Keeney M, Yang F*. "The Future of Biologic Coatings for Orthopaedic Implants", Biomaterials, 2013 Apr; 34(13):3174-83. Epub 2013 Feb 4. | Article

Yang F*, Goldberg M, Langer R, Anderson DG. "Development of Biomaterials for Delivery of Nucleic Acid Therapeutics", Modern Biopharmaceuticals. (in press) | Article

2012

Cho SW#, Yang F#, Son SM, Park HJ, Green JJ, Bogatyrev S, Mei Y, Park S, Langer R, Ander DG. "Therapeutic Angiogenesis using genetically engineered human endothelial cells." ,J. of Conrolled Release 2012 Jun 28;160(3):515-24. Epub 2012 Mar 15. (#: equal contribution). | Article

Deveza L, Choi J, Yang F*. "Therapeutic Angiogenesis for Treating Cardiovascular Diseases." Theranostcis. 2012;2(8):801-14. Epub 2012 Aug 16. | Article

Park HJ, Yang F*, Cho SW. "Nonviral Delivery of Genetic Medicine for Therapeutic Angiogenesis." Advanced Drug Delivery Review. 2012 Jan; 64(1):40-52. Epub 2011 Sep 24. | Article

Lai JH, Ramasubranian A, Jeeawoody S, Yang F*. "Nanomaterials for Engineering Cell Microenvironment and Gene delivery." Tissue Engineering and Regenerative Medicine: A Nano Approach, CRC Press, 2012. | Article

2011

Ramasubramanian A, Shiigi S, Lee GK, Yang F*. "Non-viral delivery of indutive and suppressive signals to adipose-derived stem cells for osteogenic differentiation." Pharm Res. 2011 Jun;28(6):1328-37. Epub 2011 Mar 19. | Article

 

Mass M, Guo P, Keeney M, Yang F*, Hsu TM, Fuller GG, Martin CR, Zare RN. "Bio-inspired mineralized nanofibers prepared by nanoporous membranes.", Nano Lett. 2011 Mar 9;11(3):1383-8. Epub 2011 Jan 31. | Article

Keeney M, Han LH, Onyiah S, Yang F*. "Tissue Engineering: Focus on musculoskeletal system." Biomaterials Science-an integrated clinical and engineering approach. CRC Press, 2012.

Keeney M, Lai J, Yang F*. "Recent Progress in Cartilage Tissue Engineering." Curr Opin Biotechnol. 2011 Oct; 22(5):734-40. Epub 2011 Apr 29. | Article

Before Joining Stanford

Wang DA, Williams CG, Yang F , Elisseeff JH, “Enhancing the Tissue-Biomaterial Interface: Tissue initiated Integration of Biomaterials", Advanced Functional Materials, 2004 Dec 14(12): 1152-1159. | Article

Wang DA, Williams CG, Yang F, Cher N, Lee H, Elisseeff JH, "Bioresponsive Phosphoester Hydrogels for Bone Tissue Engineering", Tissue Engineering, 2005 Jan-Feb;11(1-2):201-213. | Article

Yang F , Williams CG, Wang DA, Lee H, Manson P, Elisseeff JH, “The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells”. Biomaterials, 2005 Oct;26(30):5991- 5998. | Article

 

Wang YL, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai JL, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff JH, Huso DL, Jabs EW, “Abnormalities in Cartilage and Bone Development in the Apert Syndrome FGFR2(+/S252W) Mouse”, Development. 2005 Aug; 132(15):3537-3548. | Article

 

Reyes J MG, Fermanian S., Yang F, Zhou SY, Herretes S, Murphy DB, Elisseeff JH, Chuck RS, “Metabolic Changes in Mesenchymal Stem Cells in Osteogenic Media Measured by autofluorescence Spectroscopy”, Stem Cells. 2006 May; 24(5):1213-1217. | Article

 

Yang F* , Wang YL, Zhang Z, Hsu Bryan, Jabs EW, Elisseeff JH, “The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model”. Bone, 2008 Jul; 43(1):55-63. | Article

 

Yang F* , Mei Y, Langer R, Anderson DG. “High-throughput Optimization of Stem Cell Microenvironments”. Combinatorial Chemistry & High Throughput Screening. 2009 12(6), 544-553. | Article

 

Cho SW, Hartle L, Son SM, Yang F* , Goldberg M, Xu Q, Langer R, Anderson DG. “Delivery of Small Interfering RNA for Inhibition of Endothelial Cell Apoptosis by Hypoxia and Serum Deprivation”. Biochemical and Biophysical Communications 2008 Nov 7;376(1):158-63. | Article

 

Yang F, Green JJ, Dinio T, Keung L, Cho SW, Park H, Langer R, Anderson DG. “Gene Delivery to Human Adult and Embryonic cell-derived Stem Cells Using Biodegradable Nanoparticulate Polymeric Vectors”. Gene Therapy, 16(4), 533-546. 2009. | Article

 

Sunshine J, Green JJ, Mahon K, Yang F , Langer R, and Anderson DG. "Small Molecule End Group of Linear Polymer Determines Cell-type Gene Delivery Efficacy. " Advanced Materials 2009, 21: 1-5. | Article

Cho SW, Goldberg M, Son SM, Xu Q, Yang F, Mei Y, Bogatyrev S, Langer R, Anderson DG. "Lipid-like nanoparticles for small Interfering RNA delivery to endothelial Cells. " Advanced Functional Materials, 19 (19):3112-3118, 2009. | Article

Yang F#, Cho SW#, Son SM, Botatyrev S, Singh D, Green JJ, Mei Y, Park S, Bhang, SH, Kim BS, Langer R, Anderson DG. “Genetic engineering of human stem Cells for enhanced angiogenesis using biodegradable polymeric nanoparticles”. Proc Natl Acad Sci USA, 2010 Feb 23; 107(8):3317-22. Epub 2009 Oct 5 2009. (#: equal contribution) | Article

Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG. "Combinatorial Extracellular Matrices for Human Embryonic Stem Cell Differentiation in 3D.", Biomacromolecules. 2010 Aug 9;11(8):1909-14. Epub 2010 Jul 9. | Article

Abrahamsson C#, Yang F#, Park H, Brunger J, Valonen P, Langer R, Welter J, Caplan A, Guilak F, Freed L. "Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on 3D-woven scaffolds.", Tissue Engineering Part A. 2010 Dec;16(12):3709-18. Epub 2010 Sep 6. (#: equal contribution) | Article

Elisseeff J, Puleo C, Yang F, Sharma B, “Advances in Skeletal Tissue Engineering with Hydrogels”. Orthod Craniofac Res 2005 Aug; 8(3): 150-61. | Article

Yang F, Elisseeff JH, “Cartilage Tissue Engineering”. Biomedical Engineering Handbook, Tissue Engineering Section, (2006). | Article

Yang F, Neeley WL, Moore MJ, Karp JM, Shukla A, Langer R. “Tissue Engineering: The Therapeutic Strategy of the 21st Century”. Nanotechnology and Tissue Engineering. (2008) | Article